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KMID : 0861020080230020151
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Korea Journal of Herbology
2008 Volume.23 No. 2 p.151 ~ p.157
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Study on Biological Effect of Multi-Herbal Drug KOCO-P1 on Mouse Macrophage Raw 264.7 Cells
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Park Wan-Su
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Abstract
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Objectives: The purpose of this study is to investigate the biological Effect of multi-herbal drug ‘KOCO-P1’ on mouse macrophage Raw 264.7 cells.
Methods: Multi-herbal drug ’KOCO-P1’ was composed of Ginseng Radix, Astragali Radix, Polygonati Rhizoma, Liriopis Tuber, and Scrophulariae Radix. Cytotoxicity and cytoprotective activity of KOCO-P1 was verificated by MTT assay. And antioxidative effect of KOCO-P1 against EtOH, Nicotine was inspected by Hydroperoxide assay.
Results: KOCO-P1 showed no cytotoxicity on RAW 264.7 cells for 24, 48, 72 hours. KOCO-P1 at 200, 100, and 50 ug/mL reduced the production of H2O2 in Raw 264.7 cells by EtOH. KOCO-P1 at 50 ug/mL reduced the production of H2O2 in Raw 264.7 cells by Nicotine.
Conclusions: KOCO-P1 could be supposed to have antioxidative effect on macrophage with no cytotoxicity
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KEYWORD
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Macrophage, Immuno activity, Multi-Herbal Durg, Cytotoxicity, Antioxidative Effect
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